BIOCHEMISTRY & MOLECULAR BIOLOGY
HIGHER NERVOUS SYSTEM
KAMPO MEDICINE
Dr. HIROYUKI OHYAMA.$B!J(BPh.D$B!K(B
$B!!(B$B!!(BAge-related difference in synaptosomal membrane fluidity
Biochemistry and Molecular Biology International 37,133-140,1995
Hiroyuki Ohyama, Midori Hiramatsu, Norio Ogawa, Akitane Mori
Department of Neuroscience, Institute of Molecular and Cellular Medicine,
Okayama University Medical School, 2-5-1 Shikatacho, Okayama 700, Japan
and *Division of Medical Science, Institute for Life Support Technology, Yamagata Technopolis Foundation,
Yamagata 683 Kurumanomae, Numagi, Yamagata 990, Japan
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Dr. HIROYUKI OHYAMA$B!J(BPh.D$B!K(B in 1995.
Age-related difference in synaptosomal membrane fluidity
Biochemistry and Molecular Biology International 37,133-140,1995
Hiroyuki Ohyama, Midori Hiramatsu, Norio Ogawa, Akitane Mori
Department of Neuroscience, Institute of Molecular and Cellular Medicine,
Okayama University Medical School, 2-5-1 Shikatacho, Okayama 700, Japan
and *Division of Medical Science, Institute for Life Support Technology, Yamagata Technopolis Foundation,
Yamagata 683 Kurumanomae, Numagi, Yamagata 990, Japan
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Produced by
Dr. HIROYUKI OHYAMA.$B!J(BPh.D$B!K(B
Depertment of Neurochemistry, Institute for Neurobiology,
Okayama University Medical School
$B!J(B Director : Professor Akitane Mori $B!K(B
March 28, 1995
Reference
1) Effect of Kampo Medicine Preparations Using the Pathological Model of Dementia
Michihiro Fujiwara
Brain Research Conference for Japanese Kampo Medicine
pp.67-81,1990
2) Mixed Japanese Herbs and Age-Related Neuronal Functions
Midori Hiramatsu and Makiko Komatsu
Antioxidant Food Supplements in Human Health,edited by Lester Packer,
Midori Hiramatsu,Toshikazu Yoshikawa,
pp.412-428,1999
3) Effects of Japanese herbal medicine(TJ-960), on neuronal membrane fluidity of mice
Hiroyuki Ohyama,Midori Hiramatsu,Rei Edamatsu,Akitane Mori.
Magnetic Resonance in Medicine
6,279-281,1995
4) Antioxidant effect of TJ-960, a Japanese herbal medicine, against free radical-induced neuronal cell damage
Akitane Mori, Hajime Hamada, Hiroyuki Ohyama, Midori Hiramatsu, Seiichi Shinohara
International Symposium on Natural Antioxidants: Molecular Mechanisms and Health Effects(ISNA),
pp.45-53.1996
5) Effect of TJ-960 on generalized seizure in amygdaloid kindled cats
Susumu Iizuka, Atsushi Ishige, Kyoji Sekiguchi, Akira Sugimoto, Kouichi Itoh, Masaki Aburada, Eikichi Hosoya, Eiichi Sugaya
Recent Advances in the Pharmacology of Kampo Medicines
pp.62-68,1988
6) Normalizing effect of SK commercial formula on cytochalasin-B
distorted neurites using primary cultured neurons of rat cerebeal cortex
Aiko Sugaya, Mitsutoshi Yuzurihara, Tadashi Tsuda, Eiichi Sugaya
J. Ethnopharmacol., 21: 193-199,1987.
7) Effect of Kampo Medicine Preparations Using the Pathological Model of Dementia
Michihiro Fujiwara
Brain Research Conference for Japanese Kampo Medicine
pp.67-81,1990
Copyright Kobunsha
$BBg%Y%9%H%;%i!<(B
$B8wJ8
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KAPPA BOOKS
ISBN4-334-00650-7
C0247 $B!o(B819
1991
" THE KAMPO "
" KAMPO $B4AJ}(B "
How the Japanese Updated Traditional Herbal Medicine
Akira Tsumura, the Author$B!!(B
About the Author :
Akira Tsumura has unique qualifications to brief us in the Western world
on the history and benefits of Japanese herbal medicine.
The pharmaceutical firm he heads has a long family tradition.
Tsumura, Inc. was founded by his grandfather, Jusha Tsumura,
and has diversified to become the leading supplier of herbal medicinals.
Sub-sidiaries in the United States are well-known distributors
of health and beauty care products.
At Tsumura, Inc. scientists using the latest technology
are testing the properties of various ancient Kampo medication.
In the Tokyo suburb of Tsuchiura, the firm has constructed a modern,
high-tech factory using robots for difficult research procedures.
The auther also has a warm appreciation of the needs
and attitudes of the American people.
His interest in Western culture has remained strong since he pursued a degree
in business management at the University of Michigan in Ann Arbor.
He has formed his own Dixieland jazz group in Japan, the Storyville Dandies !!!
His collection of vintage banjoes is the best in the world.$B!!(B
" THE KAMPO "
1991
$B!!(B$B!!(B$B;qNADs6!(B
$BBg;34AJ}F2Lt6I(B
KAMPO MEDICINE
Tradition Guiding Innovation
Report of the 100th Anniversary International
Kampo Symposium '93 Tokyo, Japan
9-10 April 1993
Medicines of Plant Origin
Patient Benefit and
Japanese Kampo Therapy 1991
$B!!!!!!!!!!!!(B
Program and Book of Abstracts
Report of an International Scientific
Workshop held in Bergen, Norway
31 May 1991
$B!!(BRecent Advances in the Pharmacology of
KAMPO MEDICINES
$B!J(BJAPANESE HERBAL MEDICINES$B!K(B
Proceedings of the Satellite Meeting on Kampo$B!J(BJapanese Herbal$B!K(B Medicines
of the 10th International Congress of Pharmacology,
Auckland, New Zealand, August 19-21, 1987
$B!!!!!!(B
Basic and Clinical Studies of TJ-23 on Alzheimer's Dementia
Brain Research Conference for Japanese Kampo Medicine
1990
$B!!!!(B$B!!!!(B$B!!!!(B$B!!!!(B$B!!!!(B$B;qNADs6!(B
$BBg;34AJ}F2Lt6I(B
The First International Conference on Senescence: The SAM Model
March 17-18,1994$B!!(BKyoto, Japon
PROCEEDINGS OF THE FIRST SAM KYOTO SYMPOSIUM
$B!!(B
THE COUNCIL FOR SAM RESEARCH
Dept.of pathology chest disease res.inst.,
Kyoto university,Japan.1988
$B!!!!(B$B!!!!(B$B!!!!(B$B!!!!(B$B!!!!(BThis Issue Devoted to
Proceedings of the 18th Collegium Internationale
Neuro-Psychopharmacologicum Congress
Clinical Neuropharmacology
$B!!(B
$B!!(B
$B!!(B
Collegium Internationale Neuro-Psychopharmacologium
18th C.I.N.P. CONGRESS
ACROPOLIS Convention Center,
Nice, France
June 28 - July 2, 1992
$B!!!!(B$B!!!!(B$B!!!!(B$B;qNADs6!(B
$BBg;34AJ}F2Lt6I(B
$B!!(BMedicines of Plant Origin in Modern Therapy
from the 4th World Conference on Clinical Pharmacology, Prague 1989
A SYMPOSIUM REPORT
Published by Oxford Clinical Communications,
1989
$B!!(B$B!!(BThe English Guide to Medicinal Plants
and Kampo Formulae
1993
$B!!!!!!(B
HERBAL MEDICINE : KAMPO,
Past and Present
1985
$B;qNADs6!(B
$BBg;34AJ}F2Lt6I(B
$B!!(BEUROPEAN JOURNAL OF PHARMACOLOGY
11th International Congress of Pharmacology
Amsterdam, The Netherlands
1-6 July, 1990
$B!!!!(B$B!!!!(B$B!!!!(B$B!!!!(B$B!!!!(BFree Radicals in Brain Physiology and Disorders
An International Conference
Held in Celebration of the Retirement of Professor Akitane Mori
$B!!!!!!!!(B
August 4 and 5, 1995
International Convention Center PAMIR,
Tokyo,Japan
$B!!!!(B$B!!!!(B$B;qNADs6!(B
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' sohhaku OHYAMA ' memorial
Institute of Natural Health Science
$BBg;3=!GlElMN0e3X5-G04[(B
Image of Ohyama Kampo
" KEIRAKU."
Kampo brewer
Medicine chests
Image of Ohyama Kampo
Prescription drawer chest found in pharmacies during the edo period
Kampo brewer made of metal
Used to grind crude drugs made of metal
Medicine chests
Image of Ohyama Kampo
Image of Ohyama Kampo
sohhaku OHYAMA memorial
Oriental Medicine
$B!J(BKampo medicines, Acupuncture & Moxibustion$B!K(B
Museum
$B!V(B1006$B!W(B
$B!V(BNAMBU]
$B!V(BGOTOKU$B!W(B
$B!V(BYAKUKAN, YAKUTUBO & GOTOKU$B!W(B
$B!!(B
$B!V(BMedicine Cases$B!W(B
$B!!!!!!(B
$B!V(BMedicine Cabinets$B!W(B
$B!V(BHaribako$B!W(B
Acupuncture & Moxibustion Box
Acupuncture & Moxibustion Box
$B!V(BKyubako$B!W(B
$B!V(BSAMURAI$B!W(B
the edo period
$B!V(BATSUHIME$B!W(B
$B!V(BYAKUMI-TANSU$B!W(B
Image of Ohyama Kampo
JAPANESE HERBAL MEDICINES
KAMPO MEDICINES
JAPANESE HERBAL MEDICINES
KAMPO MEDICINES
Image of Ohyama Kampo
$B!!!!(B$B!!!!(B$B!!!!(B$B!!!!(B$B!!!!(BReference
BIOCHEMISTRY & MOLECULAR BIOLOGY
A.S.B.M.B
$B!!!!(B$B!!!!(B$B!!!!(B
DR.HIROYUKI OHYAMA$B!J(BPh.D$B!K(B
1)
Age-related difference in synaptosomal membrane fluidity
Hiroyuki Ohyama, Midori Hiramatsu, Norio Ogawa, Akitane Mori
Biochemistry and Molecular Biology International 37,133-140,1995
Department of Neuroscience, Institute of Molecular and Cellular Medicine, Okayama University Medical
School, 2-5-1 Shikatacho, Okayama 700, Japan and *Division of Medical Science, Institute for Life
Support Technology, Yamagata Technopolis Foundation, Yamagata 683 Kurumanomae, Numagi, Yamagata 990, Japan
2)
Effect of Japanese herbal medicine(TJ-960) on neuronal membrane fluidity of mice
Hiroyuki Ohyama, Midori Hiramatsu, Rei Edamatsu, Akitane Mori
Magnetic Resonance in Medicine 6, 279-281, 1995
3)
Effect of Japanese herbal medicine(TJ-960), on aging
Midori Hiramatsu, Rei Edamatsu, Hiroyuki Ohyama, Akitane Mori
Lipid-Soluble Antioxidants:Biochemistry and Clinical Applications.
pp.535-552,Birkhauser Verlag,Basel,1992
4)
Combined treatment of Japanese herbal medicine(TJ-960)with low dose of dipropylacetate increased the latent time for
pentylenetetrazol induced convulsion and decreased brain lipid peroxidation in mice.
Hiramatsu,M., Liu J, Edamatsu,R., Kadowaki,D., Hamada,H., Ohyama,H., Watanabe,S., Mori,A.
Neuroscience 18, 71-76,1992
5)
Estimation of nitric oxide and nitric oxide synthase activity in SAMP8 mouse brain
Habu,H., Yokoi,I., Kabuto,H., Ohyama,H., Mori,A., Teraoka,H., Komaru,N.
in: The SAM Model of Senescence (T.Takeda, ed.) pp.343-346,Elsevier Science B.V., Amsterdam, 1994
6)
Age-related changes in nitric oxide content and nitric oxide synthase activity
in senescence-accelerated mouse (SAM P8) brain
Yokoi,I., Inada,K., Habu,H., Kabuto,H., Mori,A., Ohyama,H., Iwaya,K., Koyama,S., Nishijima,Y., Nishijima,K.
in: Oxidative Stress and Aging (R.G.Cutler, L.Packer, J.Bertram, A.Mori, eds.)
pp387-391, Birkhauser Verlag, Basel, 1995
7)
UNESCO / Costam Workshop on Lipid-soluble Antioxidants in Biochemistry of Nutrition and Environmental Health
1991.9.21 (Malaysia)
Effect of Japanese herbal medicine(TJ-960), on aging
Midori Hiramatsu, Rei Edamatsu, Hiroyuki Ohyama, Akitane Mori
8)
Society for Free Radical Research 1991.9027 (Paris)
Japanese herbal medicine(TJ-960) affected free radicals, SOD activity,
lipid peroxidation and neurotransmitter in aged rat brain
Midori Hiramatsu, Rei Edamatsu, Hiroyuki Ohyama, Akitane Mori
9)
5th International Congress on Oxygen Radicals 1991.11.18 (Kyoto)
Decreased membrane fluidity in rat synaptosomes induced by active oxygen species,
guanidino compounds and convulsants
Midori Hiramatsu, Rei Edamatsu, Hajime Hamada, Hiroyuki Ohyama, Akitane Mori
10)
5th International Congress on Oxygen Radicals 1991.11.20 (Kyoto)
Antioxidant effects of the extracts of gastrodia fleta bl. and uncaria rhynchophylla (MJQ) jacks
Jiankang Liu, Hajime Hamada, Hiroyuki Ohyama, Akitane Mori.
11)
The First International Conference on Senescence: The SAM Model 1994.3.17 (Kyoto)
Estimation of nitric oxide and nitric oxide synthase activity in SAMP8 mouse brain
Habu,H., Yokoi,I., Kabuto,H., Ohyama,H., Mori,A., Teraoka,H., Komaru,N.
12)
The First International Conference on Oxidative Stress and Aging 1994.3.25 (Hawaii)
Age-associated changes in nitric oxide (NO) content and nitric oxide synthase (NOS) activity
in senescence accelerated mouse (SAM P8) brain
Yokoi,I., Inada,K., Habu,H., Kabuto,H., Mori,A., Ohyama,H., Iwaya,K., Koyama,S., Nishijima,Y., Nishijima,K.
13)
International Conference on Bioradicals Detected by ESR Spectroscopy 1994.6.13 (Yamagata)
Effect of Japanese herbal medicine(TJ-960) on neuronal membrane fluidity of mice
Hiroyuki Ohyama, Midori Hiramatsu, Rei Edamatsu, Akitane Mori
14)
International Symposium on Natural Antioxidants: Molecular Mechanisms and Health Effects (ISNA) 1995.6.21 (Beijin)
Antioxidant defenses of Japanese herbal medicine(TJ-960) , against free radical induced neural cell damages
Akitane Mori, Hajime Hamada, Hiroyuki Ohyama, Midori Hiramatsu, Seiichi Shinohara
Reference
1)
Mixed Japanese Herbs and Age-Related Neuronal Functions
Midori Hiramatsu and Makiko Komatsu
Antioxidant Food Supplements in Human Health,edited by Lester Packer,
Midori Hiramatsu,Toshikazu Yoshikawa,pp.412-428,1999
2)
Effects of Japanese herbal medicine(TJ-960), on neuronal membrane fluidity of mice
Hiroyuki Ohyama,Midori Hiramatsu,Rei Edamatsu,Akitane Mori.
Magnetic Resonance in Medicine 6,279-281,1995
3)
Antioxidant effect of TJ-960, a Japanese herbal medicine, against free radical-induced neuronal cell damage
Akitane Mori, Hajime Hamada, Hiroyuki Ohyama, Midori Hiramatsu, Seiichi Shinohara
International Symposium on Natural Antioxidants: Molecular Mechanisms and Health Effects(ISNA),pp.45-53.1996
4)
Effect of TJ-960 on generalized seizure in amygdaloid kindled cats
Susumu Iizuka, Atsushi Ishige, Kyoji Sekiguchi, Akira Sugimoto, Kouichi Itoh, Masaki Aburada, Eikichi Hosoya, Eiichi Sugaya
Recent Advances in the Pharmacology of Kampo Medicines pp.62-68,1988
5)
Normalizing effect of SK commercial formula on cytochalasin-B distorted neurites using primary cultured neurons of rat cerebeal cortex
Aiko Sugaya, Mitsutoshi Yuzurihara, Tadashi Tsuda, Eiichi Sugaya
J. Ethnopharmacol., 21: 193-199,1987.
6)
Effect of Kampo Medicine Preparations Using the Pathological Model of Dementia
Michihiro Fujiwara
Brain Research Conference for Japanese Kampo Medicine pp.67-81,1990
7)
Estimation of nitric oxide and nitric oxide synthase activity in SAMP8 mouse brain
Habu,H.,Yokoi,I.,Kabuto,H.,Ohyama,H.,Mori,A.,Teraoka,H.,Komaru,N.
The SAM Model of Senescence(T.Takeda,ed.) pp.343-346,
Elsevier Science B.V.,Amsterdam,1994
8)
Mixed Natural Antioxidants
Hiramatsu,M.
Food and Free Radicals,edited by Hiramatsu et al.
Plenum Press,New York,pp.113-117,1997
DR.HIROYUKI OHYAMA$B!J(BPh.D$B!K(B
BIOCHEMISTRY & MOLECULAR BIOLOGY
HIGHER NERVOUS SYSTEM
KAMPO MEDICINE
Dr. HIROYUKI OHYAMA.$B!J(BPh.D$B!K(B
1999
$B!!!!(B$B!!!!(B$B!!!!(BReference
A.S.B.M.B
BIOCHEMISTRY & MOLECULAR BIOLOGY
$B!!!!(B$B!!!!(B$B!!!!(B$B!!!!(B$B!!!!(B
References $B#1(B
(1) Whitehouse P.J., Price D.L. and Struble R.G. Alzheimer's disease and senile dimentia: loss of neurons in the basal forebrain. Science 215, 1237-1239, 1982.
(2) Price D.L., Whitehouse P.J. and Struble R.G. Alzheimer's diseases. Ann. Rev. Med. 36, 349-356, 1985.
(3) Appleyard M.E., Smith A.D., Wilcock G.K and Esiri M.M. Decreased CSF acetylcholinesterase activity in Alzheimer's disease. Lancet 20, 452, 1983
(4) Lovell M.A., Ehmann W.D., Butler S.M. and Markesbery W.R. Elevated thiobarbituric acid reactive substances and antioxident enzyme activity
in the brain in Alzheimer's disease. Neurology 45, 1594-1601, 1995.
(5)Mutisya E.M., Bowling A.B. and Beal M.F. Cortical cytochrome oxidase activity is reduced in Alzheimer's disease. J. Neurochem. 63, 2179-2184, 1994.
(6) Hensley K., Carney J.M., Mattson M.P., Aksenova M., Harris M., Wu J.F. and Floud R.A. A model for $B&A(B-amyloid aggregation and neurotoxicity based
on free radical generation by the peptide: Relevance to Alzheimer disease. Proc. Natl. Acad. Sci. USA 91, 3270-3274, 1994.
(7) Kasai H. and Nishimura S. Hydroxylation of deoxyguanosine at the C-8 position by ascorbic acid and other reducing agents. Nucleic Acids Res. 12, 2137-2145, 1984.
(8) Shibutani S., Takeshita M. and Grollman A.P. Insertion of specific nases during DNA synthesis past the oxidation damage base 8-oxodG. Nature 349, 431-434, 1991.
(9) Cheng K.C., Cahill D.S., Kasai H., Nishimura S. and Loeb L.A. 8-Hydroxyguanine, an abundant form of oxidative DNA damage,
causes G$B"*(BT and A$B"*(BC substitutions. J. Biol. Chem. 267, 166-172, 1992.
(10) Prasad G.S., Lovell M.A. and Markesbery W.R. Increased nuclear DNA oxidation in the brain in Alzheimer's diseases. J. Neurochem. 71, 2034-2040, 1998.
(11) Sohal R.S., Agarwal S. and Sohal B.H. Oxidative stress and aging in the Mongolian gerbil (Meriones unquiculatus). Mech. Ageing and Dev. 81, 15-25, 1995.
(12) Asuncion J.G., Millan A., Pla R., Bruseghini L, Esteras A., Pallardo F.V., Sastre J. and Vina J. Mitochondrial glutathione oxidation correlates
with age-associated oxidative damage to mitochondrial DNA. FASEB J. 10, 333-338, 1996.
(13) Sastre J., Millan A., Asuncion J.G., Pla R., Juan G., Pallardo F., O'Conner E., Martin J.A., Droy-Refaix M.T. and Vina J. A Ginkgo biloba extract (EGb 761)
prevents mitochondrial aging by protecting against oxidative stress. Free Rad. Biol. Med. 24, 298-304, 1998.
(14) Mecocci P., Fano G., Fulle S., MacGarvey U., Shinobu L., Polidori M.C., Cherubini A., Vecchiet J., Senin U. and Beal M.F. Age-dependent increases
in oxidative damage to DNA, lipids, and proteins in human skeletal muscle. Free Rad. Biol. Med. 26, 303-308, 1999.
(15) Ciani E., Groneng L., Voltattorni M., et al. Inhibition of free radical production or free radical scavenging protects from the excitotoxic cell death mediated
by glutamate in cultures of cerebellar granule neurons., Brain Res. 728, 1-6, 1996.
(16) Dawson V.L. and Dawson T.M. Free radicals and neuronal cell death. Cell Death and Differentiation 3, 71-78, 1996.
(17) Pillot T., Drouet B., Queille S., Labeur C., Vandekerckhove J., Rosseneu M., Pincon-Raymond M. and Chambaz J.
The nonfibrillar amyloid _-peptide induces apoptotic neuronal cell death: Involvement of its c-terminal fusogenic domain. J. Neurochem. 73, 1626-1634, 1999.
(18) Herbison A.E., Augood S.J. and Slmonian S.X. Regulation of GABA transport activity and mRNA expression
by estrogen in rat preoptic ares. J. Neurosci. 15, 8302-8309, 1995.
References 2
1. Chartier-Harlin,M.C. et al. Early-onset Alzheimer's disease caused bymutations at codon precursor protein gene. Nature 353, 844-846 (1991).
2. Sherrington,R.et al. Cloning of a gene bearing missense mutations inearly-onset familial Alzheimer's disease. Nature 375, 754-760 (1995).
3. Rogaev,E.I. et al. Familial Alzheimer's disease in kindreds withmissense mutations in a gene on chromosome 1 related to the Alzheimer'sdisease type 3 gene. Nature 376, 775-778 (1995).
4. Borchelt,D.R. et al. Familial Alzheimer's disease-linked presenilin 1variants elevate Abeta1-42/1-40 ratio in vitro and in vivo. Neuron 17,1005-1013 (1996).
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BIOCHEMISTRY & MOLECULAR BIOLOGY
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Okayama University Medical School, 2-5-1 Shikatacho, Okayama 700, Japan
and *Division of Medical Science, Institute for Life Support Technology, Yamagata Technopolis Foundation,
Yamagata 683 Kurumanomae, Numagi, Yamagata 990, Japan
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